Amyloid risk models



These models are for research or education purposes only. Further validation is warrented before they are being implemented in clinical practice.

The probability output is derived from logistic regression models that have been estblished in the Swedish BioFINDER study (http://biofinder.se) on non-demented individuals with subjective (SCD) or objective (MCI) mild cognitive impairment with accuracies (AUCs) of 0.81-0.83. They have subsequently been replicated in the ADNI study (http://adni-info.org) with similar accuracies (AUCs 0.81-0.82). The error bars represent the 95% CI of the model.

The plasma AB42/40 models described in the publication have not been implemented on this website since we believe further research is needed in terms of assay standardisation and preanalytical protocols.

Reference: Palmqvist et al. Alzheimers Dement. 2018 Oct 23, doi: 10.1016/j.jalz.2018.08.014

App developed by Niklas Mattsson, Sebastian Palmqvist and Philip Insel 2017-2018