The probability output is derived from logistic regression models that have been estblished in the Swedish BioFINDER study (http://biofinder.se) on non-demented individuals with subjective (SCD) or objective (MCI) mild cognitive impairment with accuracies (AUCs) of 0.81-0.83. They have subsequently been replicated in the ADNI study (http://adni-info.org) with similar accuracies (AUCs 0.81-0.82). The error bars represent the 95% CI of the model.
The plasma AB42/40 models described in the publication have not been implemented on this website since we believe further research is needed in terms of assay standardisation and preanalytical protocols.
Reference: Palmqvist et al. Alzheimers Dement. 2018 Oct 23, doi: 10.1016/j.jalz.2018.08.014
App developed by Niklas Mattsson, Sebastian Palmqvist and Philip Insel 2017-2018